新型杂芳基苯磺酰胺类基质金属蛋白酶抑制剂
New heteroarylbenzenesulphonamides as matrix metalloproteinase inhibitors.
作者信息
Delbecq Frédéric, Cordonnier Guy, Pommery Nicole, Barbry Didier, Hénichart Jean-Pierre
机构信息
Groupe de Recherches sur l'Inhibition de la Prolifération Cellulaire UPRES EA 2692, Equipe de Chimie Organique, Université des Sciences et Technologies de Lille, F-59655 Villeneuve d'Ascq, France.
出版信息
Bioorg Med Chem Lett. 2004 Mar 8;14(5):1119-21. doi: 10.1016/j.bmcl.2003.12.076.
PMID:14980648
Abstract
A series of derivatives of 2,4- and 2,5-thiazolyl- or oxazolylbenzenesulphonamides has been prepared and evaluated as potential MMP inhibitors. The thiazole 15b have been found to exhibit MMP-2 and MMP-9 inhibitions higher than reference compounds GI 129471 and CGS 27023A.
摘要
已制备了一系列2,4-和2,5-噻唑基或恶唑基苯磺酰胺衍生物，并将其作为潜在的基质金属蛋白酶（MMP）抑制剂进行了评估。已发现噻唑15b对MMP-2和MMP-9的抑制作用高于参考化合物GI 129471和CGS 27023A。
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