Yu Kuo-Long, Zhang Yi, Civiello Rita L, Trehan Ashok K, Pearce Bradley C, Yin Zhiwei, Combrink Keith D, Gulgeze H Belgin, Wang Xiangdong Alan, Kadow Kathleen F, Cianci Christopher W, Krystal Mark, Meanwell Nicholas A
Department of Chemistry, The Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, CT 06492, USA.
Bioorg Med Chem Lett. 2004 Mar 8;14(5):1133-7. doi: 10.1016/j.bmcl.2003.12.072.
Structure-activity relationships for a series of benzimidazol-2-one-based inhibitors of respiratory syncytial virus are described. These studies focused on structural variation of the benzimidazol-2-one substituent, a vector inaccessible in a series of benzotriazole derivatives on which 2 is based, and revealed a broad tolerance for substituent size and functionality.
描述了一系列基于苯并咪唑-2-酮的呼吸道合胞病毒抑制剂的构效关系。这些研究集中在苯并咪唑-2-酮取代基的结构变化上，该取代基在2所基于的一系列苯并三唑衍生物中是无法触及的，并且揭示了对取代基大小和官能团的广泛耐受性。
