Valenta Claudia, Schultz Katharina
Institute of Pharmaceutical Technology and Biopharmaceutics, University of Vienna, Althanstrasse 14, A-1090 Vienna, Austria.
J Control Release. 2004 Mar 5;95(2):257-65. doi: 10.1016/j.jconrel.2003.11.020.
Three different microemulsions (A-C) and one semisolid preparation D were investigated in terms of viscoelastic properties and skin permeation of the model compound sodium fluorescein. The influence of the polysaccharide carrageenan on these parameters was investigated. Carrageenan is frequently used as food additive and has very interesting properties like good adhesiveness on skin which can be a benefit for topical application. The viscoelastic properties of the preparations (A-D) and of mixtures with carrageenan (A'-D') were characterized by oscillatory measurements. It was possible to adjust the rheologic properties of the formulations and to increase the sodium fluorescein permeation through porcine skin by mixing them with carrageenan gels. Therefore, the presented formulations as well as mixtures with carrageenan might be promising alternative drug carrier systems for topical pharmaceutical as well as cosmetics.
研究了三种不同的微乳剂（A - C）和一种半固体制剂D的粘弹性特性以及模型化合物荧光素钠的皮肤渗透性。研究了多糖卡拉胶对这些参数的影响。卡拉胶常用作食品添加剂，具有非常有趣的特性，如对皮肤有良好的粘附性，这对局部应用可能有益。通过振荡测量对制剂（A - D）以及与卡拉胶的混合物（A' - D'）的粘弹性特性进行了表征。通过将它们与卡拉胶凝胶混合，可以调节制剂的流变学特性并增加荧光素钠透过猪皮肤的渗透率。因此，所呈现的制剂以及与卡拉胶的混合物可能是局部用药以及化妆品方面有前景的替代药物载体系统。
