Káli Szabolcs, Dayan Peter
Institute of Experimental Medicine, Hungarian Academy of Sciences, P.O. Box 67, Budapest 1450, Hungary.
Nat Neurosci. 2004 Mar;7(3):286-94. doi: 10.1038/nn1202. Epub 2004 Feb 22.
During sleep, neural activity in the hippocampus and neocortex seems to recapitulate aspects of its earlier, awake form. This replay may be a substrate for the consolidation of long-term declarative memories, whereby they become independent of the hippocampus and are stored in neocortex. In contrast to storage, other crucial facets of competent long-term memory, such as maintenance of access to stored traces and preservation of their correct interpretation, have received little attention. We investigate long-term episodic and semantic memory in a theoretical model of neocortical-hippocampal interaction. We find that, in the absence of regular hippocampal reactivation, even supposedly consolidated episodic memories are fragile in the face of cortical semantic plasticity. Replay allows access to episodes stored in the hippocampus to be maintained, by keeping them in appropriate register with changing neocortical representations. Hippocampal storage and replay also has a constructive role in the recall of structured, semantic information.
在睡眠期间，海马体和新皮质中的神经活动似乎重现了其早期清醒状态下的某些方面。这种重演可能是长期陈述性记忆巩固的基础，借此这些记忆变得独立于海马体并存储在新皮质中。与存储不同，有效长期记忆的其他关键方面，如对存储痕迹的访问维持和对其正确解释的保留，却很少受到关注。我们在一个新皮质 - 海马体相互作用的理论模型中研究长期情景记忆和语义记忆。我们发现，在没有海马体定期再激活的情况下，即使是假定已巩固的情景记忆，面对皮质语义可塑性时也很脆弱。重演通过使存储在海马体中的情景与不断变化的新皮质表征保持适当的对应关系，从而维持对这些情景的访问。海马体存储和重演在结构化语义信息的回忆中也具有建设性作用。
