Kondo H, Iseki T, Goto S, Takaso T, Ohto M, Okuda K
Division of Internal Medicine, Shimizu Kousei Hospital, Shizuoka, Japan.
Int J Hematol. 1992 Jun;55(3):293-300.
To examine the effects and optimal dose of danazol on idiopathic thrombocytopenic purpura (ITP), we administered a low-medium dose to 14 patients with this disease. A low-medium dose of danazol was effective in maintaining the platelet count at a high level, even after the dose of prednisolone was reduced. A low-medium dose of danazol without other therapy was effective in 3 of 6 patients even after they had been refractory to other treatment. A low dose of danazol was also effective in some patients for whom the other regimes were not indicated. It is concluded that a low-medium dose of danazol instead of a high dose is worth trying in ITP when the patient has become refractory to other therapeutic approaches or when these are not indicated.
为研究达那唑对特发性血小板减少性紫癜（ITP）的疗效及最佳剂量，我们对14例该病患者给予了低-中剂量的达那唑。即使在泼尼松龙剂量降低后，低-中剂量的达那唑仍能有效维持血小板计数在较高水平。6例患者中有3例在对其他治疗无效后，仅使用低-中剂量的达那唑且无其他治疗，病情仍有改善。低剂量的达那唑对一些不适合其他治疗方案的患者也有效。结论是，当患者对其他治疗方法无效或不适合时，低-中剂量的达那唑而非高剂量的达那唑值得在ITP治疗中尝试。
