用达那唑治疗一名患有常见可变免疫缺陷的慢性免疫性血小板减少性紫癜患者。
Danazol therapy for chronic immune-mediated thrombocytopenic purpura in a patient with common variable immunodeficiency.
作者信息
Saulsbury F T, Bringelsen K A
机构信息
Department of Pediatrics, University of Virginia Health Sciences Center, Charlottesville 22908.
出版信息
Am J Pediatr Hematol Oncol. 1991 Fall;13(3):326-9. doi: 10.1097/00043426-199123000-00014.
We describe a patient with common variable immunodeficiency (CVI) and chronic immune-mediated thrombocytopenic purpura (ITP), refractory to treatment with corticosteroids, splenectomy, and intravenous immunoglobulin. He had a prompt response to danazol, and the platelet counts have been maintained in the normal range with low-dose, alternate-day, danazol therapy. This case provides evidence that danazol is effective in the treatment of chronic ITP in patients with immunodeficiency and indicates that some patients can be maintained on an alternate-day regimen.
我们描述了一名患有常见可变免疫缺陷（CVI）和慢性免疫介导性血小板减少性紫癜（ITP）的患者，该患者对皮质类固醇、脾切除术和静脉注射免疫球蛋白治疗均无效。他对达那唑迅速产生反应，并且通过低剂量、隔日的达那唑治疗，血小板计数一直维持在正常范围内。该病例证明达那唑对免疫缺陷患者的慢性ITP治疗有效，并表明一些患者可以采用隔日疗法维持治疗。
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