Orecchia G, Perfetti L
Clinica Dermosifilopatica, Università di Pavia, Italia.
Dermatology. 1992;184(2):120-3. doi: 10.1159/000247517.
In order to evaluate the efficacy of topical khellin the vitiligo macules of one side only were painted in 41 patients with a 2% solution of khellin in acetone and propylene glycol (90 and 10%, respectively) and exposed to sunlight for a period of 4 months with 3 weekly applications and with exposure times up to 90 min. The macules of the other side were treated in 36 of the 41 patients with acetone and propylene glycol only and sun-exposed with the same schedule, while in the remaining 5 patients they were neither treated with khellin or placebo nor sun-exposed. No significant difference was evidenced between the khellin and placebo-treated sides: no excellent result (repigmentation more than 75% of the affected area) was found, and good results (repigmentation more than 50%) were found in 24.9% of khellin- plus sunlight-treated macules and in 22.3% of placebo- plus sunlight-treated macules.
为了评估外用凯林的疗效，仅对41例患者一侧的白癜风斑用2%凯林丙酮和丙二醇溶液（分别为90%和10%）进行涂抹，并每周3次暴露于阳光下4个月，暴露时间长达90分钟。41例患者中有36例另一侧的斑仅用丙酮和丙二醇处理，并按相同方案进行阳光照射，而其余5例患者既未用凯林也未用安慰剂处理，也未进行阳光照射。凯林处理组和安慰剂处理组之间未发现显著差异：未发现极佳效果（色素沉着超过受累面积的75%），24.9%接受凯林加阳光照射的斑和22.3%接受安慰剂加阳光照射的斑出现良好效果（色素沉着超过50%）。
