Kunzi Myriam S, Pitha Paula M
The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University, Baltimore, MD, USA.
Autoimmunity. 2003 Dec;36(8):457-61. doi: 10.1080/08916930310001605855.
Type I Interferons (IFN) induce the expression of IFN-stimulated genes (ISG). The products of some of these genes have direct antiviral effects, others are involved in immunoregulation or modulate signaling pathways and gene expression, and others yet are mediators of cell growth and death. Their role in autoimmune diseases has been found to be both beneficial and detrimental.
I型干扰素（IFN）可诱导干扰素刺激基因（ISG）的表达。其中一些基因的产物具有直接抗病毒作用，其他基因参与免疫调节或调节信号通路及基因表达，还有一些基因是细胞生长和死亡的介质。它们在自身免疫性疾病中的作用既有有益的一面，也有有害的一面。
