Müller U, Steinhoff U, Reis L F, Hemmi S, Pavlovic J, Zinkernagel R M, Aguet M
Institute of Molecular Biology I, University of Zürich, Switzerland.
Science. 1994 Jun 24;264(5167):1918-21. doi: 10.1126/science.8009221.
Mice lacking the known subunit of the type I interferon (IFN) receptor were completely unresponsive to type I IFNs, suggesting that this receptor chain is essential for type I IFN-mediated signal transduction. These mice showed no overt anomalies but were unable to cope with viral infections, despite otherwise normal immune responses. Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.
缺乏I型干扰素（IFN）受体已知亚基的小鼠对I型干扰素完全无反应，这表明该受体链对于I型干扰素介导的信号转导至关重要。这些小鼠没有明显异常，但尽管免疫反应在其他方面正常，却无法应对病毒感染。对缺乏I型或II型干扰素受体的小鼠进行比较表明，至少在对某些病毒的反应中，两种干扰素系统对于抗病毒防御都是必不可少的，并且在功能上不可相互替代。
