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紫外线、角膜中的促氧化剂/抗氧化剂失衡与眼部氧化损伤。

UV Rays, the prooxidant/antioxidant imbalance in the cornea and oxidative eye damage.

作者信息

Cejková J, Stípek S, Crkovská J, Ardan T, Pláteník J, Cejka C, Midelfart A

机构信息

Department of Eye Histochemistry and Pharmacology, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Vídenská 1083, 14220, Prague 4, Czech Republic.

出版信息

Physiol Res. 2004;53(1):1-10.

Abstract

In this minireview, the factors involved in the development of corneal injury due to an increased amount of UVB rays are summarized. Experimental studies have shown that an increased number of UVB rays leads to a profound decrease in corneal antioxidants (high molecular weight, antioxidant enzymes as well as low molecular weight, mainly ascorbic acid) so that a prooxidant/antioxidant imbalance appears. The decrease of corneal antioxidant protective mechanisms results in oxidative injury of the cornea and causes damage of the inner parts of the eye by UVB rays and by reactive oxygen species generated by them.

摘要

在这篇综述中,总结了因中波紫外线(UVB)辐射量增加而导致角膜损伤的相关因素。实验研究表明,UVB辐射量增加会导致角膜抗氧化剂(高分子量抗氧化剂、抗氧化酶以及低分子量抗氧化剂,主要是抗坏血酸)大幅减少,从而出现促氧化剂/抗氧化剂失衡。角膜抗氧化保护机制的降低会导致角膜氧化损伤,并使眼睛内部受到UVB射线及其产生的活性氧的损害。

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