Behrens Georg, Li Ming, Smith Christopher M, Belz Gabrielle T, Mintern Justine, Carbone Francis R, Heath William R
Immunology Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
Immunol Cell Biol. 2004 Feb;82(1):84-90. doi: 10.1111/j.1440-1711.2004.01211.x.
In this review, we examine the emerging view that all CTL responses depend on CD4 T-cell help for the generation of efficient memory. We further review the evidence that CD4 and CD8 T cells must recognize antigen on the same dendritic cell, and examine why this corecognition is required. Earlier studies have suggested that CD4 T cells must activate the dendritic cell via CD40 to license it for the capacity to prime CTL immunity. More recently, however, CD40 signalling of the CTL has been reported. Here, we argue that the main reason for corecognition of antigen on the dendritic cell may be related to the time taken to activate and release CD4 and CD8 T cells from their priming dendritic cell. CD4 T cells may only be capable of activating one dendritic cell during the period that CD8 T cells are primed. In this case, corecognition of this same dendritic cell would be essential.
在本综述中，我们探讨了一种新出现的观点，即所有细胞毒性T淋巴细胞（CTL）反应在产生高效记忆方面都依赖于CD4 T细胞的辅助。我们进一步回顾了CD4和CD8 T细胞必须在同一树突状细胞上识别抗原的证据，并研究了为何需要这种共同识别。早期研究表明，CD4 T细胞必须通过CD40激活树突状细胞，使其具备启动CTL免疫的能力。然而，最近有报道称CTL存在CD40信号传导。在此，我们认为树突状细胞上抗原共同识别的主要原因可能与从启动树突状细胞激活并释放CD4和CD8 T细胞所需的时间有关。在CD8 T细胞启动的期间，CD4 T细胞可能仅能激活一个树突状细胞。在这种情况下，对同一个树突状细胞的共同识别就至关重要。
