Greene Elizabeth S, Abdelli Nedra, Dridi Jalila S, Dridi Sami
Department of Poultry Science, University of Arkansas, Fayetteville, AR 72701, USA.
Animal Nutrition and Welfare Service, Department of Animal and Food Sciences, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.
Vet Sci. 2022 Apr 1;9(4):171. doi: 10.3390/vetsci9040171.
Neuropeptide Y (NPY) is one of the most abundant and ubiquitously expressed neuropeptides in both the central and peripheral nervous systems, and its regulatory effects on feed intake and appetite- have been extensively studied in a wide variety of animals, including mammalian and non-mammalian species. Indeed, NPY has been shown to be involved in the regulation of feed intake and energy homeostasis by exerting stimulatory effects on appetite and feeding behavior in several species including chickens, rabbits, rats and mouse. More recent studies have shown that this neuropeptide and its receptors are expressed in various peripheral tissues, including the thyroid, heart, spleen, adrenal glands, white adipose tissue, muscle and bone. Although well researched centrally, studies investigating the distribution and function of peripherally expressed NPY in avian (non-mammalian vertebrates) species are very limited. Thus, peripherally expressed NPY merits more consideration and further in-depth exploration to fully elucidate its functions, especially in non-mammalian species. The aim of the current review is to provide an integrated synopsis of both centrally and peripherally expressed NPY, with a special focus on the distribution and function of the latter.
神经肽Y（NPY）是中枢和外周神经系统中表达最为丰富且分布广泛的神经肽之一，其对采食量和食欲的调节作用已在包括哺乳动物和非哺乳动物在内的多种动物中得到广泛研究。事实上，在包括鸡、兔、大鼠和小鼠在内的多个物种中，NPY已被证明通过对食欲和摄食行为产生刺激作用，参与采食量和能量稳态的调节。最近的研究表明，这种神经肽及其受体在包括甲状腺、心脏、脾脏、肾上腺、白色脂肪组织、肌肉和骨骼在内的各种外周组织中均有表达。尽管在中枢方面已有充分研究，但探究外周表达的NPY在鸟类（非哺乳动物脊椎动物）中的分布和功能的研究非常有限。因此，外周表达的NPY值得更多关注并进行更深入的探索，以充分阐明其功能，特别是在非哺乳动物物种中的功能。本综述的目的是对中枢和外周表达的NPY进行综合概述，特别关注后者的分布和功能。
