Khan Md Sakirul Islam, Nakano Yasunori, Tachibana Tetsuya, Ueda Hiroshi
Department of Bioresource Production Science, United Graduate School of Agricultural Sciences, Ehime University, Matsuyama 790-8566, Japan.
Comp Biochem Physiol A Mol Integr Physiol. 2008 Mar;149(3):325-9. doi: 10.1016/j.cbpa.2008.01.011. Epub 2008 Jan 17.
Nitric oxide (NO) is known as an orexigenic factor in the brain of mammals and mediates the feeding-stimulatory effect of other factors such as neuropeptide Y (NPY). In neonatal chicks, however, we recently reported that NO might have an anorexigenic effect and suggested that the feeding-regulatory mechanism in chicks might be different from that in mammals regarding NO. In the present study, we investigated the involvement of NO in the effect of other orexigenic and anorexigenic factors in neonatal chicks. Intracerebroventricular co-injection of N(G)-nitro-l-arginine methyl ester (l-NAME), a NO synthase inhibitor, did not affect NPY- and prolactin-releasing peptide-induced feeding behavior. On the other hand, the co-injection of l-NAME significantly attenuated the anorexigenic effect of corticotropin-releasing hormone (CRH). The anorexigenic effects of glucagon-like peptide-1, alpha-melanocyte-stimulating hormone and ghrelin were not affected by the l-NAME treatment. These results suggest that NO might mediate the anorexigenic effect of CRH in the brain of neonatal chicks.
一氧化氮（NO）在哺乳动物大脑中被认为是一种促食欲因子，并介导其他因子（如神经肽Y，NPY）的促进食刺激作用。然而，我们最近报道，在新生雏鸡中，NO可能具有抑制食欲的作用，并表明雏鸡的进食调节机制在NO方面可能与哺乳动物不同。在本研究中，我们调查了NO在新生雏鸡中对其他促食欲和抑食欲因子作用的参与情况。脑室内共同注射NO合酶抑制剂N（G）-硝基-L-精氨酸甲酯（L-NAME）并不影响NPY和催乳素释放肽诱导的进食行为。另一方面，L-NAME的共同注射显著减弱了促肾上腺皮质激素释放激素（CRH）的抑食欲作用。胰高血糖素样肽-1、α-黑素细胞刺激素和胃饥饿素的抑食欲作用不受L-NAME处理的影响。这些结果表明，NO可能介导新生雏鸡大脑中CRH的抑食欲作用。
