Terpstra Antonius H M
Department of Laboratory Animal Science, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands.
Am J Clin Nutr. 2004 Mar;79(3):352-61. doi: 10.1093/ajcn/79.3.352.
Studies in mice have indicated that feeding diets containing 0.5-1% conjugated linoleic acid (CLA) considerably reduces body fat. These findings have attracted much interest because of the potential use of CLA as a tool to promote weight loss in humans. Several CLA studies in humans have now been published, and the objective of the present review was to give an overview of these experiments. Most of the studies were done in free-living subjects and were not strictly controlled for nutrient and energy intakes. None of the studies found a significant reduction in body weight, and only 2 studies showed a significant but relatively small body fat-lowering effect. Some studies suggested that CLA may have a tendency to increase lean body mass. Furthermore, there are indications from animal studies that CLA may have effects on plasma lipids. However, only one study in humans showed a significant HDL-cholesterol-lowering effect of CLA; in all the other studies, there were no significant effects on plasma total, LDL-, and HDL-cholesterol concentrations or on plasma triacylglycerol concentrations. Thus, the results of the studies in humans indicate that the effect of CLA on body fat is considerably less than that anticipated from mice studies and that CLA has no major effect on plasma lipids.
对小鼠的研究表明，喂食含有0.5 - 1%共轭亚油酸（CLA）的饮食可显著减少体脂。由于CLA有可能作为促进人类减肥的工具，这些发现引起了广泛关注。目前已发表了几项关于CLA在人体中的研究，本综述的目的是对这些实验进行概述。大多数研究是在自由生活的受试者中进行的，没有严格控制营养和能量摄入。没有一项研究发现体重有显著下降，只有两项研究显示出显著但相对较小的降低体脂效果。一些研究表明CLA可能有增加瘦体重的趋势。此外，动物研究表明CLA可能对血浆脂质有影响。然而，在人体研究中只有一项研究显示CLA有显著降低高密度脂蛋白胆固醇的效果；在所有其他研究中，CLA对血浆总胆固醇、低密度脂蛋白胆固醇和高密度脂蛋白胆固醇浓度或血浆三酰甘油浓度均无显著影响。因此，人体研究结果表明，CLA对体脂的影响远小于小鼠研究预期的效果，并且CLA对血浆脂质没有主要影响。
