使用ROMP凝胶负载的1-重氮基-2-氧代丙基膦酸乙酯进行末端炔烃的平行合成。
Parallel synthesis of terminal alkynes using a ROMPgel-supported ethyl 1-diazo-2-oxopropylphosphonate.
作者信息
Barrett Anthony G M, Hopkins Brian T, Love Andrew C, Tedeschi Livio
机构信息
Department of Chemistry, Imperial College London, Exhibition Road, London SW7 2AZ, England.
出版信息
Org Lett. 2004 Mar 4;6(5):835-7. doi: 10.1021/ol049915z.
PMID:14986987
Abstract
ROMPgel-supported ethyl 1-diazo-2-oxopropylphosphonate has been prepared, and the supported reagent has been effectively employed in the conversion of a variety of aldehydes into terminal alkynes under mild reaction conditions. The influence of cross-link structure, comonomers, and polymer structure on reaction efficiency has been examined. [structure: see text]
摘要
已制备了ROMP凝胶负载的1-重氮基-2-氧代丙基膦酸乙酯，并且该负载型试剂已在温和的反应条件下有效地用于将多种醛转化为末端炔烃。研究了交联结构、共聚单体和聚合物结构对反应效率的影响。[结构：见正文]
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