来自斜叶番泻的抗分枝杆菌萘并吡喃酮。

Antimycobacterial Naphthopyrones from Senna obliqua.

作者信息

Graham James G, Zhang Hongjie, Pendland Susan L, Santarsiero Bernard D, Mesecar Andrew D, Cabieses Fernando, Farnsworth Norman R

机构信息

Program for Collaborative Research in the Pharmaceutical Sciences, Department of Medicinal Chemistry, University of Illinois at Chicago, 833 S. Wood Street, Chicago, Illinois 60612, USA.

出版信息

J Nat Prod. 2004 Feb;67(2):225-7. doi: 10.1021/np030348i.

DOI:10.1021/np030348i

PMID:14987063

Abstract

Bioactivity-directed fractionation of the methanolic extract of the stem and fruits of Senna obliqua led to the isolation of two known antimycobacterial natural products, quinquangulin (1) and rubrofusarin (2). Both compounds had minimum inhibitory concentrations (MICs) of 12.0 microg/mL against Mycobacteriatuberculosis in radiometric culture. This is the first report of antimycobacterial activity associated with naphthopyrone compounds. Their structures were determined by spectroscopic means including 1D and 2D NMR techniques and further confirmed by X-ray crystallographic analysis.

摘要

对番泻叶茎和果实的甲醇提取物进行生物活性导向的分级分离，得到了两种已知的抗分枝杆菌天然产物，五光菌素（1）和红镰菌素（2）。在放射测量培养中，这两种化合物对结核分枝杆菌的最低抑菌浓度（MIC）均为12.0微克/毫升。这是关于萘并吡喃酮化合物具有抗分枝杆菌活性的首次报道。它们的结构通过包括一维和二维核磁共振技术在内的光谱手段确定，并通过X射线晶体学分析进一步证实。