来自蘑菇星裂盘菌的具有抗结核活性的羊毛甾烷型三萜类化合物。
Lanostane-type triterpenes from the mushroom Astraeus pteridis with antituberculosis activity.
作者信息
Stanikunaite Rita, Radwan Mohamed M, Trappe James M, Fronczek Frank, Ross Samir A
机构信息
Department of Pharmacognosy, School of Pharmacy, The University of Mississippi, University, Mississippi 38677, USA.
出版信息
J Nat Prod. 2008 Dec;71(12):2077-9. doi: 10.1021/np800577p.
Bioassay-guided fractionation of an EtOH extract of the truffle-mimiking mushroom Astraeus pteridis led to the isolation and identification of three new (3-5) and two known (1, 2) lanostane triterpenes and phenylalanine betaine (6). The structures of the isolates were elucidated on the basis of 1D and 2D NMR spectroscopic data, HRESIMS results, and X-ray crystallographic analysis. Compounds 5 and 1 showed moderate activity against Mycobacterium tuberculosis with MIC values of 34.0 and 58.0 microg/mL, respectively.
对模仿块菌的蘑菇星裂硬皮地星乙醇提取物进行生物测定导向的分级分离，导致分离并鉴定出三种新的（3 - 5）和两种已知的（1, 2）羊毛甾烷三萜以及苯丙氨酸甜菜碱（6）。根据一维和二维核磁共振光谱数据、高分辨电喷雾电离质谱结果以及X射线晶体学分析阐明了分离物的结构。化合物5和1对结核分枝杆菌显示出中等活性，其最低抑菌浓度值分别为34.0和58.0微克/毫升。
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