Shigemori Hideyuki, Kobayashi Jun'ichi
Institute of Applied Biochemistry, University of Tsukuba, Tsukuba 305-8572, Japan.
J Nat Prod. 2004 Feb;67(2):245-56. doi: 10.1021/np030346y.
Approximately 120 taxoids have been isolated to date from the Japanese yew, Taxus cuspidata. These taxoids possess various skeletons containing 5/7/6-, 6/10/6-, 6/5/5/6-, 6/8/6-, or 6/12-membered ring systems. Among the taxoids, some non-paclitaxel-type compounds have been shown to reduce CaCl(2)-induced depolymerization of microtubules, increase cellular accumulation of vincristine in multidrug-resistant tumor cells, and exhibit potent cytotoxicity. Chemical derivatization of taxoids of T. cuspidata is also reviewed.
迄今为止，已从日本红豆杉（东北红豆杉）中分离出约120种紫杉烷类化合物。这些紫杉烷类化合物具有各种骨架，包含5/7/6-、6/10/6-、6/5/5/6-、6/8/6-或6/12元环系统。在这些紫杉烷类化合物中，一些非紫杉醇型化合物已被证明可减少氯化钙诱导的微管解聚，增加多药耐药肿瘤细胞中长春新碱的细胞蓄积，并表现出强大的细胞毒性。本文还综述了东北红豆杉紫杉烷类化合物的化学衍生化。
