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神经能量学:呼唤星形胶质细胞满足饥饿的神经元。

Neuroenergetics: calling upon astrocytes to satisfy hungry neurons.

作者信息

Pellerin Luc, Magistretti Pierre J

机构信息

Institut de Physiologie, Université de Lausanne, Switzerland.

出版信息

Neuroscientist. 2004 Feb;10(1):53-62. doi: 10.1177/1073858403260159.

DOI:10.1177/1073858403260159
PMID:14987448
Abstract

Classical neuroenergetics states that glucose is the exclusive energy substrate of brain cells and its full oxidation provides all the necessary energy to support brain function. Recent data have revealed a more intricate picture in which astrocytes play a key role in supplying lactate as an additional energy substrate in register with glutamatergic activity.

摘要

经典神经能量学认为,葡萄糖是脑细胞唯一的能量底物,其完全氧化可提供支持脑功能所需的所有能量。最近的数据揭示了一幅更为复杂的图景,即星形胶质细胞在与谷氨酸能活动协同提供乳酸作为额外能量底物方面发挥着关键作用。

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