单不饱和脂肪酸可防止由饱和脂肪酸、血清剥夺或细胞因子暴露诱导的β细胞凋亡。

Mono-unsaturated fatty acids protect against beta-cell apoptosis induced by saturated fatty acids, serum withdrawal or cytokine exposure.

作者信息

Welters Hannah J, Tadayyon Moh, Scarpello John H B, Smith Stephen A, Morgan Noel G

机构信息

Institute of Biomedical and Clinical Science, Peninsula Medical School, Room N32, ITTC Building, Tamar Science Park, Plymouth, PL6 8BX, UK.

出版信息

FEBS Lett. 2004 Feb 27;560(1-3):103-8. doi: 10.1016/S0014-5793(04)00079-1.

DOI:10.1016/S0014-5793(04)00079-1

PMID:14988006

Abstract

Long-chain saturated fatty acids are cytotoxic to pancreatic beta-cells while shorter-chain saturated and long-chain unsaturated molecules are better tolerated. Mono-unsaturated fatty acids are not, however, inert since they inhibit the pro-apoptotic effects of saturated molecules. In the present work we show that the mono-unsaturates palmitoleate (C16:1) or oleate (C18:1) also cause marked inhibition of apoptosis induced by exposure of clonal BRIN-BD11 beta-cells to serum withdrawal or a combination of interleukin-1beta plus interferon-gamma. This response was dose-dependent and not accompanied by changes in NO formation. Taken together, the results suggest that mono-unsaturated fatty acids regulate a distal step common to several apoptotic pathways in pancreatic beta-cells.

摘要

长链饱和脂肪酸对胰腺β细胞具有细胞毒性，而短链饱和脂肪酸和长链不饱和脂肪酸分子则更易耐受。然而，单不饱和脂肪酸并非惰性物质，因为它们会抑制饱和分子的促凋亡作用。在本研究中，我们发现单不饱和脂肪酸棕榈油酸（C16:1）或油酸（C18:1）也能显著抑制克隆的BRIN-BD11β细胞因血清饥饿或白细胞介素-1β加干扰素-γ联合处理而诱导的凋亡。这种反应呈剂量依赖性，且不伴随一氧化氮生成的变化。综合来看，这些结果表明单不饱和脂肪酸调节胰腺β细胞中几种凋亡途径共有的一个远端步骤。