Qin Jian, Liu Hongjian, Wu Guozhen, Jin Minghua, Zhang Shijun, Zhang Weijun
First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080.
Zhong Yao Cai. 2003 Nov;26(11):801-4.
To find out the mechanism of Tongxinluo Capsule on anti-apoptosis of cardiac myocyte due to ischemia/reperfusion.
Mouse myocardium of ischemia/reperfusion model was observed for evaluating the activity of superoxide dismutase (SOD), the level of malondialdehyde (MDA), the apoptotic index of cardial myocyte and the expression of apoptosis correlation protein bcl-2 and bax.
Tongxinluo Capsule could raise the activity of SOD and decrease the level of MDA. And it could depress cardial myocyte apoptosis caused by ischemia/reperfusion through up-regulating bcl-2 expression and down-regulating bax expression.
Tongxinluo Capsule could protect cardial myocyte well to avoid injury due to ischemia and reperfusion.
探讨通心络胶囊抗心肌细胞缺血/再灌注凋亡的机制。
观察小鼠缺血/再灌注模型心肌中超氧化物歧化酶（SOD）活性、丙二醛（MDA）水平、心肌细胞凋亡指数及凋亡相关蛋白bcl-2和bax的表达。
通心络胶囊可提高SOD活性，降低MDA水平，上调bcl-2表达，下调bax表达，抑制缺血/再灌注所致的心肌细胞凋亡。
通心络胶囊能很好地保护心肌细胞，避免缺血及再灌注损伤。
