Chou Shih-Cheng, Lin Shong-Ling, Tseng Hui-Hwa
Department of Pathology and Laboratory Medicine, Veterans General Hospital-Kaohsiung, Kaohsiung, Taiwan, Republic of China.
Pathol Int. 2004 Mar;54(3):208-12. doi: 10.1111/j.1440-1827.2004.01609.x.
Malignant eccrine spiradenoma is an extremely rare sweat gland tumor. It may develop de novo or arise in pre-existing benign eccrine spiradenoma. However, most tumors are presented in the latter mode. The case of a 50-year-old man with malignant transformation from previously existing benign eccrine spiradenoma over his right lateral thigh is reported. Evidence for this diagnosis includes two distinct morphological components. One is the well demarcated, small round to oval benign eccrine spiradenoma and the other is the malignant element with sarcomatoid differentiation. Some foci of transition between the benign eccrine spiradenoma and the sarcomatoid part are evident and represents that the latter may arise from the former. Whether different morphological patterns influence the patients' outcome is still doubtful. However, the malignant eccrine spiradenoma is thought to have the capacity of metastasis and lethal potentiality.
恶性小汗腺螺旋腺瘤是一种极其罕见的汗腺肿瘤。它可原发发生，也可在先前存在的良性小汗腺螺旋腺瘤基础上发生。然而，大多数肿瘤以后一种方式出现。本文报道了一例50岁男性患者，其右侧大腿外侧先前存在的良性小汗腺螺旋腺瘤发生了恶变。该诊断的依据包括两个不同的形态学成分。一个是边界清楚的、小圆形至椭圆形的良性小汗腺螺旋腺瘤，另一个是具有肉瘤样分化的恶性成分。良性小汗腺螺旋腺瘤与肉瘤样部分之间的一些过渡灶很明显，表明后者可能起源于前者。不同的形态学模式是否会影响患者的预后仍不确定。然而，恶性小汗腺螺旋腺瘤被认为具有转移能力和致死潜能。
