Cooper P H, Frierson H F, Morrison A G
Arch Dermatol. 1985 Nov;121(11):1445-8.
Two patients are described in whom malignant transformation occurred within an eccrine spiradenoma. Their findings were compared with those of six similar patients from the literature, and a characteristic clinicopathologic picture was evident. The typical history was one of rapid enlargement of a cutaneous nodule of long standing. The neoplasms were composed, at least in part, of large, markedly atypical basaloid cells with numerous mitotic figures. Adjacent benign spiradenoma was observed microscopically in each case, and some of the carcinomas retained architectural features reminiscent of spiradenoma. One patient died of disseminated tumor, but follow-up was short or lacking in several cases. Malignant transformation of eccrine spiradenoma shares many clinical and pathologic features with malignant transformation of dermal cylindroma.
本文描述了两例在小汗腺螺旋腺瘤内发生恶性转化的患者。将他们的发现与文献中另外六例相似患者的发现进行了比较，从而呈现出一种典型的临床病理特征。典型病史为长期存在的皮肤结节迅速增大。肿瘤至少部分由具有大量有丝分裂象的大的、明显异型的基底样细胞组成。每例在显微镜下均观察到相邻的良性螺旋腺瘤，并且一些癌保留了让人联想到螺旋腺瘤的结构特征。一名患者死于肿瘤播散，但在几例患者中随访时间较短或缺乏随访。小汗腺螺旋腺瘤的恶性转化与皮肤圆柱瘤的恶性转化具有许多临床和病理特征。
