4例伴t(3;3)易位的急性髓系白血病患者的临床与实验室研究
[Clinical and laboratory investigation of four acute myeloid leukemia patients with t(3;3) translocation].
作者信息
Chen Zhi-mei, Wu Jian-guo, Jin Jie, Lou Ji-yu, Lin Mao-fang
机构信息
The First Affiliated Hospital of Medical College of Zhejiang University, Institute of Hematology, Hangzhou 310003, China.
出版信息
Zhonghua Xue Ye Xue Za Zhi. 2004 Jan;25(1):35-7.
OBJECTIVE
To investigate the clinical and laboratory characteristics of four acute myeloid leukemia with t(3;3) translocation.
METHODS
Bone marrow cell chromosome karyotype analysis were carried out with direct method and short-term culture and R-banding technique.
RESULTS
Four AML patients with t(3;3) translocation were identified. They did not obtain complete remission after chemotherapy and the median survival time was 4.5 months.
CONCLUSIONS
t(3;3) translocation is a rare chromosome abnormality, which has mostly been found in myeloid leukemia and the prognosis of these patients is poor.
目的
探讨4例伴有t(3;3)易位的急性髓系白血病的临床及实验室特征。
方法
采用直接法、短期培养及R显带技术进行骨髓细胞染色体核型分析。
结果
确诊4例伴有t(3;3)易位的急性髓系白血病患者。他们化疗后未获得完全缓解，中位生存时间为4.5个月。
结论
t(3;3)易位是一种罕见的染色体异常，大多见于髓系白血病，这些患者预后较差。
Zotero 插件