[中枢神经系统黑色素瘤的临床表现与治疗：15例分析]
[Clinical manifestations and treatment of melanoma of the central nervous system: analysis of 15 cases].
作者信息
Li Yong, Wang Shuo, Zhao Ji-zong
机构信息
Department of Neurosurgery, Beijing Tiantan Hospital, Beijing 100050, China.
出版信息
Zhonghua Yi Xue Za Zhi. 2004 Jan 17;84(2):134-7.
OBJECTIVE
To investigate the diagnosis and treatment of melanomas of the central nervous system.
METHODS
The clinical data, including presentation, treatment, operative finding, histological diagnosis and prognosis of 15 patients with melanomas of central nervous system who underwent surgery 1996 - 2003 were reviewed.
RESULTS
There were 12 cases of intracranial melanoma and 3 cases of spinal cord melanomas. No distinctive symptoms occurred in these patients. Total resection was achieved in 5 cases, and subtotal resection in 10 cases. Histological examination showed melanoma in 10 cases, meningeal melanocytoma in 4 cases, and amelanotic melanoma in 1 case. Ten cases were followed up for 3 months to 9 years. Among the 10 cases only 1 survived.
CONCLUSION
Melanoma of the central nervous system is an extremely rare tumor and difficult to get correct preoperative diagnosis. Microsurgery combined with radiotherapy or gamma-knife therapy is recommended. The prognosis is very poor.
目的
探讨中枢神经系统黑色素瘤的诊断与治疗。
方法
回顾性分析1996年至2003年期间接受手术治疗的15例中枢神经系统黑色素瘤患者的临床资料，包括临床表现、治疗方法、手术所见、组织学诊断及预后情况。
结果
颅内黑色素瘤12例，脊髓黑色素瘤3例。这些患者无明显特异性症状。5例行全切除，10例行次全切除。组织学检查显示黑色素瘤10例，脑膜黑色素细胞瘤4例，无色素性黑色素瘤1例。10例患者随访3个月至9年，仅1例存活。
结论
中枢神经系统黑色素瘤是一种极为罕见的肿瘤，术前难以获得正确诊断。建议采用显微手术联合放疗或伽玛刀治疗。其预后极差。
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