Ma Jun, Zhang Zhong, Li Shu, Chen Xiaolin, Wang Shuo
Department of Neurosurgery, Beijing Tiantan Hospital affiliated to Capital Medical University, China National Clinical Research Center for Neurological Diseases, Center of Brain Tumor, Beijing Institute for Brain Disorders and Beijing Key Laboratory of Brian Tumor, Beijing, 100050, China.
World J Surg Oncol. 2015 May 12;13:182. doi: 10.1186/s12957-015-0600-z.
The incidence of primary central nervous system (CNS) melanocytic neoplasms is relatively low comparing to systemic ones. The performance of the tumor is variable. With poor clinical experience, the diagnosis and treatment of such tumors present to be a challenge. Amelanotic melanoma is an especially rare subtype. Only several cases have been reported.
We report a case of intracranial amelanotic melanoma. Preoperative assessment revealed progressive right frontal mass. The patient underwent tumor resection. The pathologic analysis reported amelanotic melanoma of intermediate grade. The further examination of the whole brain and body was negative. The familial history was also negative. The patient recovered uneventfully and went on for radiotherapy and chemotherapy. After a follow-up period of 5 months, the patient was tumor-free.
This is the second report about primary CNS amelanotic melanoma. We summarized characteristics of the primary CNS melanocytic lesions and amelanotic melanoma with review of the literature and review of cases of our department.
与全身性黑素细胞肿瘤相比，原发性中枢神经系统（CNS）黑素细胞肿瘤的发病率相对较低。肿瘤的表现多样。由于临床经验不足，此类肿瘤的诊断和治疗具有挑战性。无色素性黑色素瘤是一种特别罕见的亚型。仅报道过几例。
我们报告一例颅内无色素性黑色素瘤。术前评估显示右侧额叶肿块逐渐增大。患者接受了肿瘤切除术。病理分析报告为中度无色素性黑色素瘤。全脑和全身的进一步检查均为阴性。家族史也为阴性。患者恢复顺利，并继续接受放疗和化疗。经过5个月的随访，患者无肿瘤复发。
这是关于原发性中枢神经系统无色素性黑色素瘤的第二篇报道。我们通过文献复习和对本部门病例的回顾，总结了原发性中枢神经系统黑素细胞病变和无色素性黑色素瘤的特征。
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