Courvoisie Helen, Hooper Stephen R, Fine Camille, Kwock Lester, Castillo Mauricio
Department of Psychniatry and Behavioral Sciences, Johns Hopkins University Medical School, Baltimore, Maryland 21287, USA.
J Neuropsychiatry Clin Neurosci. 2004 Winter;16(1):63-9. doi: 10.1176/jnp.16.1.63.
Proton magnetic resonance spectroscopy (MRS) and neuropsychological testing were conducted on 8 children with attention-deficit/hyperactivity disorder (ADHD-H), with no learning disabilities or comorbidities and 8 controls. Magnetic resonance spectroscopy revealed increased Glutamate/Glutamine in both frontal areas, and increased N-acetyl aspartate and Choline in the right frontal area of the ADHD-H subjects. Neuropsychological testing revealed few within- and between-group differences. Findings related to frontal lobe dysfunction in ADHD-H subjects were noted. N-acetylasparte/creatine (NAA/Creatine) in the right frontal region, and myoinositol/creatine (Myo inositol/Creatine) in the right and left frontal regions appear to be highly associated with the regulation of sensorimotor, language, and memory and learning functioning in children with ADHD-H.
对8名患有注意力缺陷多动障碍（ADHD-H）且无学习障碍或共病的儿童以及8名对照组儿童进行了质子磁共振波谱（MRS）和神经心理学测试。磁共振波谱显示，ADHD-H受试者的两个额叶区域谷氨酸/谷氨酰胺增加，右侧额叶区域N-乙酰天门冬氨酸和胆碱增加。神经心理学测试显示组内和组间差异较少。注意到与ADHD-H受试者额叶功能障碍相关的发现。右侧额叶区域的N-乙酰天门冬氨酸/肌酸（NAA/肌酸）以及左右额叶区域的肌醇/肌酸似乎与ADHD-H儿童的感觉运动、语言以及记忆和学习功能的调节高度相关。
