Luksch Harald, Khanbabaie Reza, Wessel Ralf
Institute of Biology II, Rheinisch-Westfälische Technische Hochschule Aachen, 52074 Aachen, Germany.
Nat Neurosci. 2004 Apr;7(4):380-8. doi: 10.1038/nn1204. Epub 2004 Feb 29.
Humans and other animals generally perceive motion independently of the cues that define the moving object. To understand the underlying mechanisms of this generalization of stimulus attributes, we have examined the cellular properties of avian wide-field tectal neurons that are sensitive to a variety of moving stimuli but not to static stationary stimuli. This in vitro study showed phasic signal transfer at the retinotectal synapse and binary dendritic responses to synaptic inputs that interact in a mutually exclusive manner in the postsynaptic tectal neuron. A model of the tectal circuitry predicts that these two cellular properties mediate sensitivity to a wide range of dynamic spatiotemporal stimuli, including moving stimuli, but not to static stationary stimuli in a tectal neuron. The computation that is independent of stimulus detail is initiated by tectal neurons and is completed by rotundal neurons that integrate outputs from multiple tectal neurons in a directionally selective manner.
人类和其他动物通常独立于定义移动物体的线索来感知运动。为了理解这种刺激属性泛化的潜在机制，我们研究了禽类广域顶盖神经元的细胞特性，这些神经元对多种移动刺激敏感，但对静态刺激不敏感。这项体外研究表明，在视网膜顶盖突触处存在相位信号传递，并且在突触后顶盖神经元中，对以互斥方式相互作用的突触输入存在二元树突反应。顶盖神经回路模型预测，这两种细胞特性介导了对广泛动态时空刺激（包括移动刺激）的敏感性，但对顶盖神经元中的静态刺激不敏感。与刺激细节无关的计算由顶盖神经元启动，并由以方向选择性方式整合多个顶盖神经元输出的圆核神经元完成。
