Kaufman Howard L, Disis Mary L
Department of Surgery, Columbia University, New York, New York 10032, USA.
J Clin Invest. 2004 Mar;113(5):664-7. doi: 10.1172/JCI21148.
Despite the initial excitement over cancer vaccines, the clinical effectiveness of immunotherapy has been disappointing. The suppressive milieu present within established tumors inhibits effective immune responses, although new strategies are emerging to manipulate the local tumor microenvironment and shift the balance back to a proinflammatory environment, promote DC activation, and enhance tumor immunity.
尽管最初对癌症疫苗充满热情,但免疫疗法的临床效果却令人失望。既定肿瘤内存在的抑制性环境会抑制有效的免疫反应,不过新的策略正在涌现,以操控局部肿瘤微环境,将平衡重新转向促炎环境,促进树突状细胞激活,并增强肿瘤免疫力。