靶向TFIIH以抑制裂谷热病毒对宿主细胞转录的作用。

Targeting TFIIH to inhibit host cell transcription by Rift Valley Fever Virus.

作者信息

Dasgupta Asim

机构信息

Department of Microbiology, School of Medicine, University of California, Los Angeles, 10833, Le Conte Avenue, Los Angeles, CA 90095, USA.

出版信息

Mol Cell. 2004 Feb 27;13(4):456-8. doi: 10.1016/s1097-2765(04)00092-9.

DOI:10.1016/s1097-2765(04)00092-9

PMID:14992716

Abstract

In the February 20 issue of Cell, report that Rift Valley Fever Virus (RVFV) targets cellular transcriptional apparatus to inhibit RNA polymerase II-mediated transcription. Unlike polio and vesicular stomatitis viruses, both of which target the TATA binding protein (TBP), RVFV appears to target the basal transcription factor THIIH to induce shut-off of host cell transcription.

摘要

在2月20日的《细胞》杂志上，有报道称裂谷热病毒（RVFV）靶向细胞转录装置以抑制RNA聚合酶II介导的转录。与脊髓灰质炎病毒和水泡性口炎病毒不同，这两种病毒都靶向TATA结合蛋白（TBP），而RVFV似乎靶向基础转录因子THIIH以诱导宿主细胞转录关闭。