Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
Institute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control, Beijing 100013, China.
Emerg Microbes Infect. 2017 Jan 18;6(1):e4. doi: 10.1038/emi.2016.136.
We report the first imported case of Rift Valley fever (RVF) in China. The patient returned from Angola, a non-epidemic country, with an infection of a new reassortant from different lineages of Rift Valley fever viruses (RVFVs). The patient developed multiorgan dysfunction and gradually recovered with continuous renal replacement therapy and a short regimen of methylprednisolone treatment. The disordered cytokines and chemokines in the plasma of the patient revealed hypercytokinemia, but the levels of protective cytokines were low upon admission and fluctuated as the disease improved. Whole-genome sequencing and phylogenetic analysis revealed that the imported strain was a reassortant comprising the L and M genes from lineage E and the S gene from lineage A. This case highlights that RVFV had undergone genetic reassortment, which could potentially alter its biological properties, cause large outbreaks and pose a serious threat to global public health as well as the livestock breeding industry.
我们报告了中国首例输入性裂谷热（RVF）病例。该患者从安哥拉（一个非疫区国家）返回，感染了一种新的重组病毒，该病毒来自裂谷热病毒（RVFV）的不同谱系。该患者出现多器官功能障碍，并通过持续肾脏替代治疗和短程甲基强的松龙治疗逐渐康复。患者血浆中紊乱的细胞因子和趋化因子显示出高细胞因子血症，但保护性细胞因子的水平在入院时较低，随着病情的改善而波动。全基因组测序和系统进化分析表明，输入的菌株是一种重组病毒，包含来自谱系 E 的 L 和 M 基因以及来自谱系 A 的 S 基因。该病例突显了 RVFV 发生了基因重组，这可能会改变其生物学特性，导致大规模暴发，并对全球公共卫生和畜牧业造成严重威胁。
