大鼠发育大脑中fasciculation和elongation蛋白zeta-1（FEZ1）的表达
Expression of fasciculation and elongation protein zeta-1 (FEZ1) in the developing rat brain.
作者信息
Honda Akiko, Miyoshi Ko, Baba Kousuke, Taniguchi Manabu, Koyama Yoshihisa, Kuroda Shun'ichi, Katayama Taiichi, Tohyama Masaya
机构信息
Department of Brain Science, Graduate School of Medicine and Dentistry, Okayama University, Okayama 700-8558, Japan.
出版信息
Brain Res Mol Brain Res. 2004 Mar 17;122(1):89-92. doi: 10.1016/j.molbrainres.2003.11.020.
Fasciculation and elongation protein zeta-1 (FEZ1) is a mammalian homologue of the Caenorhabditis elegans UNC-76 protein involved in axonal outgrowth and fasciculation. Recently, we reported that FEZ1 interacts with Disrupted-In-Schizophrenia 1 (DISC1), a product of the candidate gene for schizophrenia, and that the interaction between these proteins has a role in neurite outgrowth. This time, we investigated the expression of FEZ1 and DISC1 in the developing rat brain using in situ hybridization. Both FEZ1 and DISC1 showed high levels of expression, especially in developing hippocampal neurons. These findings suggest the potential involvement of FEZ1 and DISC1 in the formation of hippocampal neural circuits.
成束和延伸蛋白ζ-1（FEZ1）是秀丽隐杆线虫UNC-76蛋白的哺乳动物同源物，参与轴突生长和成束。最近，我们报道FEZ1与精神分裂症候选基因的产物精神分裂症相关断裂基因1（DISC1）相互作用，并且这些蛋白之间的相互作用在神经突生长中起作用。此次，我们使用原位杂交技术研究了FEZ1和DISC1在发育中的大鼠脑中的表达。FEZ1和DISC1均表现出高水平的表达，尤其是在发育中的海马神经元中。这些发现表明FEZ1和DISC1可能参与海马神经回路的形成。
Zotero 插件