Thomson Pippa A, Malavasi Elise L V, Grünewald Ellen, Soares Dinesh C, Borkowska Malgorzata, Millar J Kirsty
The Centre for Molecular Medicine at the Medical Research Council Institute of Genetics and Molecular Medicine, The University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK.
Front Biol (Beijing). 2013 Feb 1;8(1):1-31. doi: 10.1007/s11515-012-1254-7.
Psychiatric disorders are highly heritable, and in many individuals likely arise from the combined effects of genes and the environment. A substantial body of evidence points towards DISC1 being one of the genes that influence risk of schizophrenia, bipolar disorder and depression, and functional studies of DISC1 consequently have the potential to reveal much about the pathways that lead to major mental illness. Here, we review the evidence that DISC1 influences disease risk through effects upon multiple critical pathways in the developing and adult brain.
精神疾病具有高度遗传性，在许多个体中可能是由基因和环境的综合作用引起的。大量证据表明，DISC1是影响精神分裂症、双相情感障碍和抑郁症风险的基因之一，因此对DISC1的功能研究有可能揭示许多导致重大精神疾病的途径。在这里，我们综述了DISC1通过影响发育中和成人大脑中的多个关键途径来影响疾病风险的证据。
