金背黄鼠（侧纹黄鼠）的血浆脂蛋白胆固醇浓度：冬眠前与冬眠动物的比较。

Plasma lipoprotein cholesterol concentrations in the golden-mantled ground squirrel (Spermophilus lateralis): a comparison between pre-hibernators and hibernators.

Russom J M, Guba G R, Sanchez D, Tam C F, Lopez G A, Garcia R E

Department of Biology, California State University, Los Angeles 90032.

Comp Biochem Physiol B. 1992 Jul;102(3):573-8. doi: 10.1016/0305-0491(92)90049-w.

Abstract

The concentrations of total cholesterol (free cholesterol plus cholesteryl ester) in the plasma and in two lipoprotein fractions of golden-mantled ground squirrels (Spermophilus lateralis) were measured during pre-hibernation and compared to those values measured during hibernation. 2. Hibernating ground squirrels had significantly higher (P less than 0.005) very low density lipoprotein plus low density lipoprotein cholesterol (VLDL + LDL-C) concentrations than did pre-hibernating ground squirrels. 3. Hibernating squirrels additionally exhibited significantly higher (P less than 0.005) total plasma cholesterol concentration per high density lipoprotein cholesterol concentration (TPC/HDL-C) ratios than did pre-hibernating squirrels. 4. The significant differences in the lipoprotein cholesterol concentrations observed in this study suggest that lipoprotein metabolism in pre-hibernators was significantly different from that in hibernators and was a reflection of the marked biochemical and physiological adjustments these animals must undergo during their transition from pre-hibernation to hibernation.

摘要

测定了金色mantled地松鼠（侧纹黄鼠）在冬眠前血浆及两种脂蛋白组分中总胆固醇（游离胆固醇加胆固醇酯）的浓度，并与冬眠期间测得的值进行比较。2. 冬眠的地松鼠极低密度脂蛋白加低密度脂蛋白胆固醇（VLDL + LDL-C）浓度显著高于（P小于0.005）冬眠前的地松鼠。3. 冬眠松鼠的每高密度脂蛋白胆固醇浓度的总血浆胆固醇浓度（TPC/HDL-C）比值也显著高于（P小于0.005）冬眠前的松鼠。4. 本研究中观察到的脂蛋白胆固醇浓度的显著差异表明，冬眠前动物的脂蛋白代谢与冬眠动物的脂蛋白代谢显著不同，这反映了这些动物在从冬眠前过渡到冬眠期间必须经历的显著生化和生理调节。