Brodie E E, Allan D, Brooks D N, McCulloch J, Foulds W S
Wellcome Neuroscience Group, University of Glasgow.
Cortex. 1992 Jun;28(2):289-93. doi: 10.1016/s0010-9452(13)80055-x.
P1 and P2 components of visual evoked responses (VERs) to flash stimuli were compared between patients diagnosed as suffering from Senile Dementia of the Alzheimer Type (AD) and elderly controls. Additionally the P100 component of the VER to pattern reversal stimuli at high and low contrast and using large and small check patterns was compared. Significant differences between moderate AD patients and the normal elderly were found for the P2 component of the flash stimulus and for the P100 component of the high spatial frequency pattern reversal stimuli at low contrast. These findings suggest a deficit in primary visual processing and a selective deficit in secondary visual processing in moderate cases of dementia. This indicates that visual processing capacities of AD patients decline as the disease progresses in line with the continual degeneration of neuronal populations involved with vision.
在被诊断患有阿尔茨海默型老年痴呆症（AD）的患者和老年对照组之间，比较了对闪光刺激的视觉诱发电位（VER）的P1和P2成分。此外，还比较了在高对比度和低对比度下使用大尺寸和小尺寸方格图案的模式反转刺激的VER的P100成分。在中度AD患者和正常老年人之间，发现闪光刺激的P2成分以及低对比度下高空间频率模式反转刺激的P100成分存在显著差异。这些发现表明，在中度痴呆病例中，初级视觉处理存在缺陷，二级视觉处理存在选择性缺陷。这表明，随着疾病进展，AD患者的视觉处理能力会随着参与视觉的神经元群体的持续退化而下降。
