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The TASK family: two-pore domain background K+ channels.

作者信息

Bayliss Douglas A, Sirois Jay E, Talley Edmund M

机构信息

Department of Pharmacology, School of Medicine, University of Virginia, Charlottesville, VA, USA.

出版信息

Mol Interv. 2003 Jun;3(4):205-19. doi: 10.1124/mi.3.4.205.

DOI:10.1124/mi.3.4.205
PMID:14993448
Abstract
摘要

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The TASK family: two-pore domain background K+ channels.TASK家族：双孔结构域背景钾离子通道
Mol Interv. 2003 Jun;3(4):205-19. doi: 10.1124/mi.3.4.205.
2
TASK-1 is a highly modulated pH-sensitive 'leak' K(+) channel expressed in brainstem respiratory neurons.任务-1是一种在脑干呼吸神经元中表达的高度调制的pH敏感“渗漏”钾离子通道。
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3
Expression pattern in brain of TASK-1, TASK-3, and a tandem pore domain K(+) channel subunit, TASK-5, associated with the central auditory nervous system.与中枢听觉神经系统相关的TASK-1、TASK-3和串联孔结构域钾通道亚基TASK-5在大脑中的表达模式。
Mol Cell Neurosci. 2001 Dec;18(6):632-48. doi: 10.1006/mcne.2001.1045.
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Potassium leak channels and the KCNK family of two-P-domain subunits.钾离子泄漏通道与双孔域亚基的KCNK家族
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Amide local anesthetics potently inhibit the human tandem pore domain background K+ channel TASK-2 (KCNK5).酰胺类局部麻醉药可有效抑制人类双孔域背景钾通道TASK-2（KCNK5）。
J Pharmacol Exp Ther. 2003 Jul;306(1):84-92. doi: 10.1124/jpet.103.049809. Epub 2003 Mar 26.
6
Formation of functional heterodimers between the TASK-1 and TASK-3 two-pore domain potassium channel subunits.TASK-1和TASK-3两孔结构域钾通道亚基之间功能性异源二聚体的形成。
J Biol Chem. 2002 Feb 15;277(7):5426-32. doi: 10.1074/jbc.M107138200. Epub 2001 Dec 3.
7
Two-pore domain K+ channels-molecular sensors.双孔结构域钾通道——分子传感器
Biochim Biophys Acta. 2002 Nov 13;1566(1-2):152-61. doi: 10.1016/s0005-2736(02)00597-7.
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TASK-1, a two-pore domain K+ channel, is modulated by multiple neurotransmitters in motoneurons.双孔结构域钾通道TASK-1在运动神经元中受到多种神经递质的调节。
Neuron. 2000 Feb;25(2):399-410. doi: 10.1016/s0896-6273(00)80903-4.
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Modulation of TASK-1 (Kcnk3) and TASK-3 (Kcnk9) potassium channels: volatile anesthetics and neurotransmitters share a molecular site of action.TASK-1（Kcnk3）和TASK-3（Kcnk9）钾通道的调节：挥发性麻醉剂和神经递质共享一个分子作用位点。
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10
Inhalational anesthetics activate two-pore-domain background K+ channels.吸入性麻醉药可激活双孔域背景钾通道。
Nat Neurosci. 1999 May;2(5):422-6. doi: 10.1038/8084.

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TASK1 and TASK3 Are Coexpressed With ASIC1 in the Ventrolateral Medulla and Contribute to Central Chemoreception in Rats.任务1和任务3与酸敏感离子通道1在延髓腹外侧共同表达，并参与大鼠的中枢化学感受。
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