Tao Ze-wei, Huang Yuan-wei, Xia Qiang, Fu Jun, Zhao Zhi-hong, Lu Xian, Bruce I C
Department of Cardiology, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China.
J Zhejiang Univ Sci. 2004 Apr;5(4):494-8. doi: 10.1631/jzus.2004.0494.
Myocardial infarction (MI) is the main cause of heart failure, but the relationship between the extent of MI and cardiac function has not been clearly determined. The present study was undertaken to investigate early changes in the electrocardiogram associated with infarct size and cardiac function after MI.
MI was induced by ligating the left anterior descending coronary artery in rats. Electrocardiograms, echocardiographs and hemodynamic parameters were assessed and myocardial infarct size was measured from mid-transverse sections stained with Masson's trichrome.
The sum of pathological Q wave amplitudes was strongly correlated with myocardial infarct size (r = 0.920, P < 0.0001), left ventricular ejection fraction (r = -0.868, P < 0.0001) and left ventricular end diastolic pressure (r = 0.835, P < 0.0004). Furthermore, there was close relationship between MI size and cardiac function as assessed by left ventricular ejection fraction (r = -0.913, P < 0.0001) and left ventricular end diastolic pressure (r = 0.893, P < 0.0001).
The sum of pathological Q wave amplitudes after MI can be used to estimate the extent of MI as well as cardiac function.
心肌梗死（MI）是心力衰竭的主要原因，但MI范围与心脏功能之间的关系尚未明确确定。本研究旨在探讨MI后与梗死面积和心脏功能相关的心电图早期变化。
通过结扎大鼠左冠状动脉前降支诱导MI。评估心电图、超声心动图和血流动力学参数，并从用马松三色染色的中横切片测量心肌梗死面积。
病理性Q波振幅总和与心肌梗死面积（r = 0.920，P < 0.0001）、左心室射血分数（r = -0.868，P < 0.0001）和左心室舒张末期压力（r = 0.835，P < 0.0004）密切相关。此外，通过左心室射血分数（r = -0.913，P < 0.0001）和左心室舒张末期压力（r = 0.893，P < 0.0001）评估，MI面积与心脏功能之间存在密切关系。
MI后病理性Q波振幅总和可用于估计MI范围以及心脏功能。
