Huang He, Shan Jiang, Pan Xiao-hong, Wang Hui-ping, Qian Ling-bo
Department of Cardiology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China.
J Zhejiang Univ Sci B. 2006 Sep;7(9):725-31. doi: 10.1631/jzus.2006.B0725.
Oxidative stress plays a dominant role in the pathogenesis of diabetes mellitus. Bcl-2 gene has close connection with antioxidant stress destruction in many diseases including diabetes. Carvedilol, an adrenoceptor blocker, also has antioxidant properties. To study the effect of carvedilol on the antioxidant status in diabetic hearts, we investigated carvedilol-administrated healthy and streptozotocin-induced diabetic rats. After small and large dosage carvedilol-administered for 5 weeks, hemodynamic parameters, the levels of malondialdehyde, activities of antioxidant enzymes and expression of Bcl-2 mRNA in the cardiac tissues were measured. The diabetic rats not only had cardiac disfunction, weaker activities of antioxidant enzymes, but also showed lower expression of Bcl-2. Carvedilol treatment increased activities of antioxidant enzymes and expression of Bcl-2 in healthy rats as well as diabetic rats. These results indicated that carvedilol partly improves cardiac function via its antioxidant properties in diabetic rats.
氧化应激在糖尿病发病机制中起主导作用。Bcl-2基因在包括糖尿病在内的许多疾病的抗氧化应激破坏过程中有着密切联系。卡维地洛，一种肾上腺素能受体阻滞剂，也具有抗氧化特性。为了研究卡维地洛对糖尿病心脏抗氧化状态的影响，我们对给予卡维地洛的健康大鼠和链脲佐菌素诱导的糖尿病大鼠进行了研究。在给予小剂量和大剂量卡维地洛5周后，测量血流动力学参数、心脏组织中丙二醛水平、抗氧化酶活性以及Bcl-2 mRNA的表达。糖尿病大鼠不仅存在心脏功能障碍、抗氧化酶活性较弱，而且Bcl-2表达也较低。卡维地洛治疗可提高健康大鼠和糖尿病大鼠的抗氧化酶活性以及Bcl-2表达。这些结果表明，卡维地洛在糖尿病大鼠中通过其抗氧化特性部分改善了心脏功能。
