Hattori Y, Nagashima M, Endo Y, Kanno M
Department of Pharmacology, Hokkaido University School of Medicine, Sapporo, Japan.
Eur J Pharmacol. 1992 Mar 17;213(1):147-50. doi: 10.1016/0014-2999(92)90246-z.
Vasoactive intestinal polypeptide (VIP) caused a concentration-dependent relaxation in rabbit mesenteric artery with intact endothelium. The relaxant response to VIP was inhibited by the removal of the endothelium or by pretreatment with methylene blue, but not by pretreatment with glibenclamide. A small but significant relaxant response to VIP in the endothelium-denuded artery was also unaffected by glibenclamide. These findings indicate that ATP-sensitive K+ channels are not involved in the endothelium-dependent or endothelium-independent arterial relaxation elicited by VIP.
血管活性肠肽（VIP）可使具有完整内皮的兔肠系膜动脉产生浓度依赖性舒张。去除内皮或用亚甲蓝预处理可抑制对VIP的舒张反应，但用格列本脲预处理则无此作用。内皮剥脱的动脉对VIP的微弱但显著的舒张反应也不受格列本脲影响。这些发现表明，ATP敏感性钾通道不参与VIP引起的内皮依赖性或非内皮依赖性动脉舒张。
