Govind C K
Life Sciences Division, Scarborough College, University of Toronto, Ontario, Canada.
Exp Gerontol. 1992;27(1):63-74. doi: 10.1016/0531-5565(92)90029-y.
Multiterminal innervation of a lobster limb muscle by an identified excitor motoneuron was examined during primary development and adult growth. To keep pace with the growth in the target muscle, axonal branches proliferate by sprouting from synaptic terminals; an increasingly complex branching pattern results. Neuromuscular synapses multiply in number, enlarge in size, and become perforated. Concomitantly, synapses tend to appear on the more distal axonal branches and to disappear on more proximal branches, providing for continual remodeling of multiterminal innervation. This plasticity in an identified motoneuron occurs over a long life span of several decades.
在幼年发育和成年生长过程中，对一只龙虾肢体肌肉由一个已识别的兴奋性运动神经元进行的多端神经支配进行了研究。为了跟上目标肌肉的生长，轴突分支通过从突触末端发芽而增殖；从而产生了越来越复杂的分支模式。神经肌肉突触在数量上增加、大小上增大并出现穿孔。与此同时，突触倾向于出现在更远端的轴突分支上，并在更近端的分支上消失，从而实现多端神经支配的持续重塑。这种已识别运动神经元的可塑性发生在长达数十年的寿命期间。
