Carrillo-Muñoz A J, Fernandez-Torres B, Guarro J
Department of Microbiology, ACIA, Barcelona, Spain.
J Chemother. 2003 Dec;15(6):555-7. doi: 10.1179/joc.2003.15.6.555.
Three hundred and nine strains belonging to 11 species of dermatophyte moulds were tested against sertaconazole following mainly the National Committee for Clinical Laboratory Standards (M38-P) for filamentous fungi. However, several important factors such as the temperature (28 degrees C vs 35 degrees C) and time of incubation (4-10 d vs 21-74 h), have been modified. Sertaconazole was active against all the clinically important dermatophyte moulds involved in human infections tested. Overall geometric mean MIC of sertaconazole was 0.21 microg/ml with a MIC range of 0.01-8 microg/ml. MIC50 and MIC90 were respectively of 0.25 and 1 microg/ml. Sertaconazole was very active against Epidermophyton floccosum, Trichophyton rubrum, Trichophyton tonsurans and Microsporum canis (geometric means 0.08, 0.13, 0.13 and 0.19 microg/ml respectively). Microsporum audouinii had the lowest susceptibility in the study (geometric mean 0.59 microg/ml). Considering MIC50 and MIC90 these differences were significantly in favor of the activity of sertaconazole against E. floccosum (0.06 and 0.5 microg/ml respectively).
主要按照美国国家临床实验室标准委员会（M38 - P）针对丝状真菌的方法，对属于11种皮肤癣菌的309株菌株进行了舍他康唑药敏试验。然而，几个重要因素如温度（28℃对35℃）和孵育时间（4 - 10天对21 - 74小时）已作了调整。舍他康唑对所有参与人体感染检测的临床上重要的皮肤癣菌均有活性。舍他康唑的总体几何平均MIC为0.21μg/ml，MIC范围为0.01 - 8μg/ml。MIC50和MIC90分别为0.25和1μg/ml。舍他康唑对絮状表皮癣菌、红色毛癣菌、断发毛癣菌和犬小孢子菌非常有效（几何平均值分别为0.08、0.13、0.13和0.19μg/ml）。奥杜盎小孢子菌在该研究中敏感性最低（几何平均值0.59μg/ml）。考虑到MIC50和MIC90，这些差异显著有利于舍他康唑对絮状表皮癣菌的活性（分别为0.06和0.5μg/ml）。
