Department of Microbiology-Mycology, ACIAM, Barcelona, Spain.
Chemotherapy. 2012;58(5):399-404. doi: 10.1159/000345704. Epub 2012 Dec 29.
Antifungal activity and in vitro inhibition time for sertaconazole (STZ) and 9 other topical drugs, namely amorolfine, bifonazole, clotrimazole, econazole, ketoconazole, miconazole, oxiconazole, terbinafine, and tioconazole were determined against 124 clinical isolates of dermatophyte (12 species) fungi by the microdilution method in a liquid medium and the measurement of optical density. STZ's antifungal activity was not always affected by the tested dermatophyte genus, as was the case with the remaining antifungals. In vitro antifungal activity was at the same level for all the studied azole derivatives, but, in terms of partial inhibitory concentrations, STZ starts its in vitro inhibitory activity in a shorter time than the other tested substances, particularly in those incubation periods when the growth of the dermatophyte fungi was more developed.
采用微量稀释法在液体培养基中测定了司特康唑（STZ）和其他 9 种局部用药物（阿莫罗芬、布替萘芬、克霉唑、益康唑、酮康唑、咪康唑、奥昔康唑、特比萘芬和噻康唑）对 124 株临床分离的皮肤真菌（12 种）的抗真菌活性和体外抑制时间。STZ 的抗真菌活性并不总是受测试的皮肤真菌属的影响，其余的抗真菌药物也是如此。所有研究的唑类衍生物的体外抗真菌活性水平相同，但就部分抑制浓度而言，STZ 比其他测试物质更早开始其体外抑制活性，尤其是在皮肤真菌生长更发达的孵育期。
