硝酸舍他康唑对引起足癣的红色毛癣菌、须癣毛癣菌和絮状表皮癣菌具有杀菌和抑菌活性。
Sertaconazole nitrate shows fungicidal and fungistatic activities against Trichophyton rubrum, Trichophyton mentagrophytes, and Epidermophyton floccosum, causative agents of tinea pedis.
机构信息
Department of Microbiology, ACIAM, P.O. Box 10178, E-08080 Barcelona, Spain.
出版信息
Antimicrob Agents Chemother. 2011 Sep;55(9):4420-1. doi: 10.1128/AAC.00219-11. Epub 2011 Jul 11.
Abstract
The fungistatic and fungicidal activities of sertaconazole against dermatophytes were evaluated by testing 150 clinical isolates of causative agents of tinea pedis, Trichophyton rubrum, Trichophyton mentagrophytes, and Epidermophyton floccosum. The overall geometric means for fungistatic and fungicidal activities of sertaconazole against these isolates were 0.26 and 2.26 μg/ml, respectively, although values were higher for T. mentagrophytes than for the others. This is the first comprehensive demonstration of the fungicidal activity of sertaconazole against dermatophytes.
摘要
酮康唑对皮肤癣菌的抑菌和杀菌活性通过对 150 株引起足癣的病原菌，红色毛癣菌、须癣毛癣菌和絮状表皮癣菌的临床分离株进行检测进行评估。酮康唑对这些分离株的抑菌和杀菌活性的总几何平均值分别为 0.26 和 2.26μg/ml，尽管须癣毛癣菌的值高于其他两种菌。这是首次全面证明酮康唑对皮肤癣菌的杀菌活性。
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