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Sertaconazole nitrate shows fungicidal and fungistatic activities against Trichophyton rubrum, Trichophyton mentagrophytes, and Epidermophyton floccosum, causative agents of tinea pedis.硝酸舍他康唑对引起足癣的红色毛癣菌、须癣毛癣菌和絮状表皮癣菌具有杀菌和抑菌活性。
Antimicrob Agents Chemother. 2011 Sep;55(9):4420-1. doi: 10.1128/AAC.00219-11. Epub 2011 Jul 11.
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Sertaconazole: a review of its use in the management of superficial mycoses in dermatology and gynaecology.舍他康唑：皮肤科和妇科浅表真菌病治疗应用综述
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Comparison of the in vitro activity of terbinafine and lanoconazole against dermatophytes.特比萘芬和联苯苄唑对皮肤癣菌的体外活性比较。
Mycoses. 2010 Jul;53(4):311-3. doi: 10.1111/j.1439-0507.2009.01723.x. Epub 2009 May 5.
4
Antimycotic effect in vitro of a detergent. Fungicidal and fungistatic effect of the detergent and its components on Trichophyton mentagrophytes. Trichophyton rubrum and Epidermophyton floccosum.一种洗涤剂的体外抗真菌作用。该洗涤剂及其成分对须癣毛癣菌、红色毛癣菌和絮状表皮癣菌的杀菌和抑菌作用。
Acta Derm Venereol. 1964;44(3):211-8.
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A clinical and mycologic study of tinea corporis and pedis in Puerto Rico.波多黎各体癣和足癣的临床与真菌学研究
Int J Dermatol. 1984 Oct;23(8):550-1. doi: 10.1111/j.1365-4362.1984.tb04209.x.
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Comparison of in vitro activity of undecylenic acid and tolnaftate against athlete's foot fungi.十一烯酸与托萘酯对足癣真菌的体外活性比较。
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Int J Dermatol. 1994 Oct;33(10):733-7. doi: 10.1111/j.1365-4362.1994.tb01523.x.
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Efficacy of antifungal agents against fungal spores: An in vitro study using microplate laser nephelometry and an artificially infected 3D skin model.抗真菌药物对真菌孢子的疗效：使用微孔板激光散射浊度法和人工感染的 3D 皮肤模型进行的体外研究。
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Comparison of in vitro antifungal activity of novel triazoles with available antifungal agents against dermatophyte species caused tinea pedis.比较新型三氮唑类药物与现有抗真菌药物对引起足癣的皮肤癣菌的体外抗真菌活性。
J Mycol Med. 2020 Jun;30(2):100935. doi: 10.1016/j.mycmed.2020.100935. Epub 2020 Jan 30.

引用本文的文献

1
Efficacy of antifungal agents against fungal spores: An in vitro study using microplate laser nephelometry and an artificially infected 3D skin model.抗真菌药物对真菌孢子的疗效：使用微孔板激光散射浊度法和人工感染的 3D 皮肤模型进行的体外研究。
Microbiologyopen. 2022 Feb;11(1):e1257. doi: 10.1002/mbo3.1257.
2
Antifungal Drug Susceptibility Testing of Dermatophytes: Laboratory Findings to Clinical Implications.皮肤癣菌的抗真菌药敏试验：从实验室结果到临床意义
Indian Dermatol Online J. 2019 May-Jun;10(3):225-233. doi: 10.4103/idoj.IDOJ_146_19.
3
Hydrocortisone 1% cream and sertaconazole 2% cream to treat facial seborrheic dermatitis: A double-blind, randomized clinical trial.1%氢化可的松乳膏和2%舍他康唑乳膏治疗面部脂溢性皮炎：一项双盲随机临床试验。
Int J Womens Dermatol. 2016 Dec 23;3(2):107-110. doi: 10.1016/j.ijwd.2016.11.008. eCollection 2017 Jun.
4
A comparative randomized open label study to evaluate efficacy, safety and cost effectiveness between topical 2% sertaconazole and topical 1% butenafine in tinea infections of skin.一项比较随机开放标签研究，以评估2%硝酸舍他康唑乳膏与1%布替萘芬乳膏治疗皮肤癣菌感染的疗效、安全性和成本效益。
Indian J Dermatol. 2013 Nov;58(6):451-6. doi: 10.4103/0019-5154.119955.

本文引用的文献

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Epidemiology of superficial fungal infections.浅部真菌感染流行病学。
Clin Dermatol. 2010 Mar 4;28(2):197-201. doi: 10.1016/j.clindermatol.2009.12.005.
2
Cutaneous fungal infections in the United States: Analysis of the National Ambulatory Medical Care Survey (NAMCS) and National Hospital Ambulatory Medical Care Survey (NHAMCS), 1995-2004.美国的皮肤真菌感染：1995 - 2004年国家门诊医疗护理调查（NAMCS）和国家医院门诊医疗护理调查（NHAMCS）分析
Int J Dermatol. 2009 Jul;48(7):704-12. doi: 10.1111/j.1365-4632.2009.04025.x.
3
In vitro antifungal activity of sertaconazole nitrate against recent isolates of onychomycosis causative agents.硝酸舍他康唑对甲癣病原体近期分离株的体外抗真菌活性。
J Chemother. 2008 Aug;20(4):521-3. doi: 10.1179/joc.2008.20.4.521.
4
Fungicidal versus Fungistatic: what's in a word?杀真菌与抑菌：一字之差有何区别？
Expert Opin Pharmacother. 2008 Apr;9(6):927-35. doi: 10.1517/14656566.9.6.927.
5
Dermatomycoses of the glabrous skin : a double-blind, randomised, comparative trial of sertaconazole 2% cream once daily versus vehicle.无毛皮肤的皮肤真菌病：酮康唑 2%乳膏每日一次与赋形剂的双盲、随机、对照试验。
Clin Drug Investig. 2003;23(6):387-94. doi: 10.2165/00044011-200323060-00002.
6
The safety and efficacy of sertaconazole nitrate cream 2% for tinea pedis.2%硝酸舍他康唑乳膏治疗足癣的安全性和有效性。
Cutis. 2006 Oct;78(4):268-74.
7
In vitro antifungal activity of sertaconazole compared with nine other drugs against 250 clinical isolates of dermatophytes and Scopulariopsis brevicaulis.与其他九种药物相比，舍他康唑对250株皮肤癣菌和短帚霉临床分离株的体外抗真菌活性。
Chemotherapy. 2004 Dec;50(6):308-13. doi: 10.1159/000082631. Epub 2004 Dec 8.
8
Determination of fungicidal activities against yeasts and molds: lessons learned from bactericidal testing and the need for standardization.针对酵母和霉菌的杀真菌活性测定：从杀菌测试中吸取的经验教训以及标准化的必要性。
Clin Microbiol Rev. 2004 Apr;17(2):268-80. doi: 10.1128/CMR.17.2.268-280.2004.
9
In vitro antifungal activity of sertaconazole against 309 dermatophyte clinical isolates.舍他康唑对309株皮肤癣菌临床分离株的体外抗真菌活性
J Chemother. 2003 Dec;15(6):555-7. doi: 10.1179/joc.2003.15.6.555.
10
In vitro activity of sertaconazole against dermatophyte isolates with reduced fluconazole susceptibility.舍他康唑对氟康唑敏感性降低的皮肤癣菌分离株的体外活性
Chemotherapy. 2003 Sep;49(5):248-51. doi: 10.1159/000072449.

硝酸舍他康唑对引起足癣的红色毛癣菌、须癣毛癣菌和絮状表皮癣菌具有杀菌和抑菌活性。

Sertaconazole nitrate shows fungicidal and fungistatic activities against Trichophyton rubrum, Trichophyton mentagrophytes, and Epidermophyton floccosum, causative agents of tinea pedis.

机构信息

Department of Microbiology, ACIAM, P.O. Box 10178, E-08080 Barcelona, Spain.

出版信息

Antimicrob Agents Chemother. 2011 Sep;55(9):4420-1. doi: 10.1128/AAC.00219-11. Epub 2011 Jul 11.

DOI:10.1128/AAC.00219-11
PMID:21746955
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3165331/
Abstract

The fungistatic and fungicidal activities of sertaconazole against dermatophytes were evaluated by testing 150 clinical isolates of causative agents of tinea pedis, Trichophyton rubrum, Trichophyton mentagrophytes, and Epidermophyton floccosum. The overall geometric means for fungistatic and fungicidal activities of sertaconazole against these isolates were 0.26 and 2.26 μg/ml, respectively, although values were higher for T. mentagrophytes than for the others. This is the first comprehensive demonstration of the fungicidal activity of sertaconazole against dermatophytes.

摘要

酮康唑对皮肤癣菌的抑菌和杀菌活性通过对 150 株引起足癣的病原菌，红色毛癣菌、须癣毛癣菌和絮状表皮癣菌的临床分离株进行检测进行评估。酮康唑对这些分离株的抑菌和杀菌活性的总几何平均值分别为 0.26 和 2.26μg/ml，尽管须癣毛癣菌的值高于其他两种菌。这是首次全面证明酮康唑对皮肤癣菌的杀菌活性。