丝状真菌中的细胞核迁移与定位

Nuclear migration and positioning in filamentous fungi.

作者信息

Xiang Xin, Fischer Reinhard

机构信息

Department of Biochemistry and Molecular Biology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.

出版信息

Fungal Genet Biol. 2004 Apr;41(4):411-9. doi: 10.1016/j.fgb.2003.11.010.

DOI:10.1016/j.fgb.2003.11.010

PMID:14998524

Abstract

Genetic analyses of nuclear distribution mutants have indicated that functions of the microtubule motor, cytoplasmic dynein, and its regulators are important for nuclear positioning in filamentous fungi. Here we review these studies and also present the need to further dissect how dynein and its associated microtubule cytoskeleton are involved mechanistically in nuclear positioning in the multinucleated hyphae.

摘要

对核分布突变体的遗传分析表明，微管马达、细胞质动力蛋白及其调节因子的功能对于丝状真菌中的核定位很重要。在此，我们综述这些研究，并提出进一步剖析动力蛋白及其相关微管细胞骨架如何在多核菌丝的核定位中发挥机械作用的必要性。