Molecular Mycology Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bangalore, 560064, India.
Curr Genet. 2019 Dec;65(6):1341-1346. doi: 10.1007/s00294-019-01000-x. Epub 2019 May 31.
Positioning the nucleus to a specific cellular location is a prerequisite for high-fidelity transmission of the genetic material to daughter cells. The cellular location of the nucleus just before its division is variable in budding yeast species which rely on a variety of mechanisms for nuclear division. Dynamic growth and shrinkage kinetics of microtubules (MTs) and forces exerted by the MT plus- and minus-end-directed motor proteins empower nuclear movement. Even though the overall process of nuclear migration is largely conserved across budding yeasts, in-depth molecular analyses of newly emerging model budding yeasts began to reveal striking differences from the paradigms that have been established based on the studies performed in the well-characterized budding yeast Saccharomyces cerevisiae. Here, we highlight the molecular players involved in differential nuclear migration in diverse budding yeasts.
将细胞核定位到特定的细胞位置是将遗传物质高保真地传递给子细胞的前提条件。在依赖多种核分裂机制的出芽酵母物种中，细胞核在分裂前的细胞位置是可变的。微管（MTs）的动态生长和收缩动力学以及 MT 正端和负端定向马达蛋白施加的力赋予了细胞核运动的能力。尽管核迁移的整体过程在出芽酵母中基本保守，但对新出现的模式出芽酵母的深入分子分析开始揭示出与基于在特征明确的出芽酵母酿酒酵母中进行的研究建立的范例相比的显著差异。在这里，我们强调了参与不同出芽酵母中核迁移差异的分子参与者。
