Lau Edith Ming Chu, Wong Samuel Yeung Shan, Li Martin, Ma Chun Hung, Lim Pak Leong, Woo Jean
Department of Family and Community Medicine, Chinese University of Hong Kong, Hong Kong.
J Bone Miner Metab. 2004;22(2):148-52. doi: 10.1007/s00774-003-0463-1.
Transforming growth factor-beta-1 (TGF-Beta(1)) has been implicated in bone mineral density (BMD) determination. We investigated the relationship between the TGF polymorphism, BMD, and vertebral fractures in 588 Chinese men and women. No association between TGF polymorphism and BMD was observed in postmenopausal women (aged 55-59 years), elderly men (aged 70-79 years), or elderly women (aged 70-79 years) at the hip, spine, or total body ( P >> 0.05 by two-way ANOVA). In all study groups, there was no effect of an interaction between TGF polymorphism and calcium intake on BMD ( P >> 0.05 for the interaction effects by two-way ANOVA). No statistical significant association was observed between TGF polymorphism and vertebral fracture in elderly men or women ( P >> 0.05 by the chi-square test), even though men of the TT and TC genotypes seem to have more vertebral fractures. Contrary to previous studies that found an association between BMD and TGF polymorphism in the Japanese, we found no association between TGF polymorphism and BMD of elderly Chinese men or women. This finding could result from different sampling methods between the previous and current studies and environmental factors and ethnic differences between the two populations.
转化生长因子-β1（TGF-β1）与骨密度（BMD）的测定有关。我们调查了588名中国男性和女性中TGF多态性、骨密度和椎体骨折之间的关系。在绝经后女性（55 - 59岁）、老年男性（70 - 79岁）或老年女性（70 - 79岁）的髋部、脊柱或全身，未观察到TGF多态性与骨密度之间存在关联（双向方差分析，P >> 0.05）。在所有研究组中，TGF多态性与钙摄入量之间的相互作用对骨密度没有影响（双向方差分析，相互作用效应P >> 0.05）。在老年男性或女性中，未观察到TGF多态性与椎体骨折之间存在统计学显著关联（卡方检验，P >> 0.05），尽管TT和TC基因型的男性似乎有更多的椎体骨折。与之前在日本人中发现骨密度与TGF多态性之间存在关联的研究相反，我们发现老年中国男性或女性的TGF多态性与骨密度之间没有关联。这一发现可能是由于之前和当前研究之间不同的抽样方法以及两个人群之间的环境因素和种族差异所致。
