Zhang Zhi-Chang, He Neng-Bin, Zhang Tao
Department of Orthopedics, The Sixth People's Hospital affiliated to Shanghai Jiaotong University Shanghai 200233, China.
Int J Clin Exp Med. 2014 Dec 15;7(12):5124-9. eCollection 2014.
The association between TGF-β1 +869C/T polymorphism and risk of fractures remained controversial. Therefore, we performed this meta-analysis to investigate this association. We searched PubMed, EMBASE, and Wangfang databases for studies before Aug 2014. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to calculate the strength of association. A total of ten studies were included in this meta-analysis. TGF-β1 +869C/T polymorphism was associated with a significantly increased risk of fracture (OR=1.41; 95% CI, 1.20-1.65; I(2) =0%). In the subgroup analysis according to gender, women was significantly associated with risk of fracture (OR=1.44; 95% CI, 1.20-1.73; I(2) =4%). In the subgroup analysis by race, Asians (OR=1.43; 95% CI, 1.06-1.92; I(2) =0%) and Caucasians (OR=1.44; 95% CI, 1.13-1.85; I(2) =15%) showed increased fracture risk. Our meta-analysis suggested that the TGF-β1 +869C/T polymorphism may be a risk factor for developing fracture.
转化生长因子β1（TGF-β1）+869C/T基因多态性与骨折风险之间的关联仍存在争议。因此，我们进行了这项荟萃分析来研究这种关联。我们检索了PubMed、EMBASE和万方数据库中2014年8月之前的研究。采用比值比（OR）及95%置信区间（CI）计算关联强度。本荟萃分析共纳入10项研究。TGF-β1 +869C/T基因多态性与骨折风险显著增加相关（OR=1.41；95%CI，1.20 - 1.65；I²=0%）。在按性别进行的亚组分析中，女性与骨折风险显著相关（OR=1.44；95%CI，1.20 - 1.73；I²=4%）。在按种族进行的亚组分析中，亚洲人（OR=1.43；95%CI，1.06 - 1.92；I²=0%）和高加索人（OR=1.44；95%CI，1.13 - 1.85；I²=15%）的骨折风险增加。我们的荟萃分析表明，TGF-β1 +869C/T基因多态性可能是发生骨折的一个风险因素。
