Stewart Matthew, Welter Jean F, Goldberg Victor M
Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, 1008W Hazelwood Drive, Urbana, Illinois 61802, USA.
J Biomed Mater Res A. 2004 Apr 1;69(1):1-10. doi: 10.1002/jbm.a.20071.
This study determined the effects of a plasma-sprayed hydroxyapatite/tricalcium phosphate (HA/TCP) coating on osseointegration of plasma-sprayed titanium alloy implants in a lapine, distal femoral intramedullary model. The effects of the HA/TCP coating were assessed at 1, 3, and 6 months after implant placement. The HA/TCP coating significantly increased new bone apposition onto the implant surfaces at all time points. The ceramic coating also stimulated intramedullary bone formation at the middle and distal levels of the implants. Fluorescent bone labeling indicated that new bone formation occurred primarily during the first 3 months after implantation, with comparatively little activity detected in the latter stages of the study. There was no associated increase in pullout strength at either 3 or 6 months; however, post-pullout evaluation of the implants indicated that the HA/TCP coating itself was not the primary site of construct failure. Rather, failure was most commonly observed through the periprosthetic osseous struts that bridged the medullary cavity. The demonstrated osteoconductive activity of HA/TCP coating on plasma-sprayed titanium alloy implant surfaces may have considerable clinical relevance to early host-implant interactions, by accelerating the establishment of a stable prosthesis-bone interface.
本研究在兔股骨远端髓内模型中，确定了等离子喷涂羟基磷灰石/磷酸三钙（HA/TCP）涂层对等离子喷涂钛合金植入物骨整合的影响。在植入后1、3和6个月评估HA/TCP涂层的效果。在所有时间点，HA/TCP涂层均显著增加了植入物表面的新骨附着。陶瓷涂层还刺激了植入物中、远端水平的髓内骨形成。荧光骨标记表明，新骨形成主要发生在植入后的前3个月，在研究后期检测到的活性相对较少。在3个月或6个月时，拔出强度均未相应增加；然而，植入物拔出后的评估表明，HA/TCP涂层本身不是结构失效的主要部位。相反，失效最常发生在跨越髓腔的假体周围骨支柱处。HA/TCP涂层在等离子喷涂钛合金植入物表面所显示的骨传导活性，可能通过加速稳定的假体-骨界面的建立，对早期宿主-植入物相互作用具有相当大的临床意义。
