Hoesl Cornelia E, Nefzi Adel, Houghten Richard A
Torrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, CA 92121, USA.
J Comb Chem. 2004 Mar-Apr;6(2):220-3. doi: 10.1021/cc030036y.
An efficient one-pot procedure for the solid-phase synthesis of new tetracyclic 1,3,5-triazino[1,2-a]benzimidazolium derivatives starting from resin-bound benzimidazoles is described. The synthetic strategy involves an unprecedented one-pot Aza-Wittig/heterocyclization/substitution reaction sequence using halogenoalkyl isocyanates. The structure of the tetracyclic ring system was determined by two-dimensional NMR experiments and X-ray analysis.
描述了一种从树脂结合的苯并咪唑开始高效一锅法固相合成新型四环1,3,5-三嗪并[1,2-a]苯并咪唑鎓衍生物的方法。合成策略涉及使用卤代烷基异氰酸酯进行前所未有的一锅法氮杂维蒂希/杂环化/取代反应序列。通过二维核磁共振实验和X射线分析确定了四环体系的结构。
