铜催化的多米诺加成/双环化反应：多环苯并咪唑衍生物的一种合成方法。

Copper-catalyzed domino addition/double cyclization: an approach to polycyclic benzimidazole derivatives.

机构信息

Zhejiang Key Laboratory for Reactive Chemistry on Solid Surfaces, College of Chemistry and Life Sciences, Zhejiang Normal University , Jinhua 321004, People's Republic of China.

出版信息

J Org Chem. 2014 Feb 21;79(4):1749-57. doi: 10.1021/jo402742k. Epub 2014 Feb 10.

DOI:10.1021/jo402742k

PMID:24490887

Abstract

An efficient and versatile method for the assembly of novel polycyclic benzimidazole derivatives has been developed by Cu-catalyzed domino addition/double cyclization reactions. A wide variety of polycyclic benzimidazole derivatives, which might be used as synthetic medicines and functional materials, were successfully assembled from bis-(o-haloaryl)carbodiimides. Unexpected N-methylated benzo[4,5]imidazo[1,2-a]indoles can also be selectively assembled. Multibonds and polycyclic moieties were conveniently formed in one pot during these domino processes.

摘要

一种高效、通用的新型多环苯并咪唑衍生物的组装方法，通过 Cu 催化的多步加成/双环化反应得以实现。多种多环苯并咪唑衍生物，可用作合成药物和功能材料，成功地由双（邻卤代芳基）碳二亚胺组装而成。同时，也可选择性地组装出意想不到的 N-甲基苯并[4,5]咪唑并[1,2-a]吲哚。这些多步反应中，多键和多环片段可以在一锅反应中方便地形成。